Sunlight? or UVA?Light?Mediated Synthesis of Hydroxamic Acids from Carboxylic Acids
نویسندگان
چکیده
The development of light-mediated methods for synthetic applications is increasingly attracting high interest. We present herein a new photochemical protocol the synthesis hydroxamic acids, which constitute an important class medicinal agents, mainly due to their anticancer properties. method mediated by UVA-light or sunlight and its key point generation charge transfer complex interaction 4-dimethylaminopyridine with halomethane. Various carboxylic acids were directly coupled O-protected hydroxylamines, upon irradiation either LED 370 nm solar light. A detailed study mechanism was carried out employment direct infusion–high resolution mass spectrometry (DI-HRMS), providing experimental evidence formation various activated species, may lead desired product. applied in drugs Vorinostat Bufexamac.
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ژورنال
عنوان ژورنال: European Journal of Organic Chemistry
سال: 2023
ISSN: ['1434-193X', '1099-0690']
DOI: https://doi.org/10.1002/ejoc.202300046